廈門大學(xué)醫(yī)學(xué)院中央千人計劃許華曦教授博導(dǎo)信息

許華曦教授的研究主要致力于闡明AD發(fā)病的分子機(jī)制。綜合遺傳學(xué)、神經(jīng)生物學(xué)、分子和細(xì)胞生物學(xué)信息等多學(xué)科，以闡明APP和早老素的正常生物學(xué)功能及其突變基因使蛋白發(fā)生改變而引起AD的機(jī)制。其團(tuán)隊的科研項目旨在研究Aβ轉(zhuǎn)運(yùn)和降解過程、tau蛋白異常磷酸化jfsoft.net.cn，并試圖尋找影響Aβ產(chǎn)生的新基因和遺傳通路，研究目標(biāo)在于揭示導(dǎo)致AD發(fā)病機(jī)理早期事件中的細(xì)胞和分子級聯(lián)反應(yīng)，并為開發(fā)合理的AD治療策略提供關(guān)鍵信息。
主要學(xué)術(shù)成就：
論文
1 Xu, H. ,Sweeney, D.,Wang, R., Thinakaran, G..,Lo, A.C.Y., Sisodia, S., Greengard, P., and Gandy, S. (1997) Generation of Alzheimer ß-amyloid Protein in the trans-Golgi Network in the Apparent Absence of Vesicle Formation. Proc. Natl. Acad. Sci. USA. （影響因子10.789) 94:3748-3752. 
2  Xu, H., Gouras, G. K., Greenfield, J. P., Vincent, B., Naslund, J., Mazzarelli, L., Jovanovic, J. N, Seeger, M, Relkin, N. R, Liao, F., Checler, F., Buxbaum, J. D, Chait, B. T., Thinakaran, G., Sisodia, S., Wang, R., Greengard, P., and Gandy, S. (1998). Estrogen Reduces Neuronal Generation of Alzheimer ß-amyloid Peptides.  Nature Medicine （影響因子27.905)4:447-451. 
 3 Greenfield, J. P., Tsai, J., Gouras, G. K., Hai, B., Thinakaran, G., Checler, F., Sisodia, S. S., Greengard, P., and Xu, H.* (1999) Endoplasmic Reticulum and trans-Golgi Network Generate Distinct Populations of Alzheimer ß-Amyloid Peptides.  Proc. Natl. Acad. Sci. USA （影響因子10.789)96:742-747. 
 4 Gouras, G. K.¶, Xu, H.¶, Gross, R., Greenfield, J. P., Hai, B., Wang, R., and Greengard, P.  (2000) Testosterone Reduces Neuronal Secretion of Alzheimer ß-amyloid Peptides.  Proc. Natl. Acad. Sci. USA （影響因子10.789)97:1202-1205.  (¶, equal contribution).
5 Gasparini, L., Netzer, W., Greengard, P., and Xu, H *. (2002) Does Insulin Dysfunction Play a Role in Alzheimer's Disease.  Trends in Pharmacological Sciences （影響因子13.276)23(6):288-293. 
 6 Dou, F., Netzer, W. J., Tanemura, K., Li, F., Hartl, F.U., Takashima, A., Gouras G.K., Greengard, P., and Xu, H. * (2003) Chaperones increase association of tau protein with microtubules.  Proc. Natl. Acad. Sci. USA （影響因子10.789)100:721-726. jfsoft.net.cn
7 Gasparini, L and Xu, H. * (2003) Potential roles of insulin and IGF-1 in Alzheimer's disease. Trends in Neurosciences （影響因子16.475)26(8):404-406. 
 8 Zhang, Y.W., Wang, R., Liu, Q., Zhang, H., Liao, F.F., Xu, H.* (2007) Presenilin/ g-secretase- dependent processing of APP regulates EGFR expression. Proc Natl Acad Sci USA (影響因子10.789)104: 10613-10618. 
 9 Zhang, Y.W., Liu, S., Zhang, X., Li, W.B., Chen, Y., Huang, X., Sun, L., Luo, W., Netzer, W.J., Threadgill, R., Wiegand, G., Wang, R., Cohen, SN., Greengard, P., Liao, F.F., Li, L., Xu, H..* (2009) A functional mouse retroposed gene Rps23r1 reduces Alzheimer’s b-amyloid levels and tau phosphorylation. Neuron (影響因子14.17)  64：328-340. 
 10 Zhang, Y-w., Xu, H. * (2010) Substrate check of gamma-secretase.Nat Struct Mol Biol（影   響因子12.273)17(2):140-141.

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