從1996年起先后領(lǐng)導創(chuàng)辦衛(wèi)生部中國循證醫(yī)學中心、Chinese Cochrane Center（包括香港分中心)、循證醫(yī)學教育部網(wǎng)上合作研究中心（包括12個已建成的分中心和8個在建分中心)、中國臨床試驗注冊中心（獲WHO和衛(wèi)生部共同批準的WHO國際臨床試驗注冊平臺（WHO ICTRP)全球第四個、發(fā)展中國家第一個一級注冊中心（Primary Register))及中國循證醫(yī)學雜志和Journal of Evidence-Based Medicine，并任主任和主編。領(lǐng)導創(chuàng)辦國內(nèi)第一個循證醫(yī)學（EBM)新興交叉學科，最早招收EBM研究生。主編出版國內(nèi)第一本《循證醫(yī)學》規(guī)劃教材和十一五規(guī)劃教材（高等教育出版社，2003年、2009年出版)。先后負責CMB、AusAid、WHO、衛(wèi)生部、藥監(jiān)局、科技部EBM研究、建設(shè)項目15項，經(jīng)費930余萬元。出版EBM專著、叢書、譯著17部。近5年發(fā)表EBM文章SCI收錄9篇（通訊作者7篇)、Medline收錄5篇（通訊作者4篇)、EMBASE/俄羅斯文摘收錄80余篇述評和
論著（第一作者及通訊作者)。2002年獲教育部科技進步二等獎、成都市科技進步一等獎。2007年獲準國家級精品課程，2008年獲中華醫(yī)學三等獎。2009年獲國家級優(yōu)秀教學團隊（均排名第一)和教育部教學成果二等獎（排名第二)。從2003年起，連續(xù)擔任3屆WHO基本藥物目錄評審委員會專家并參加評審；2007年1月起受聘為WHO藥物評價咨詢專家組專家，任期4年（2007.1-2011.12)。2001年創(chuàng)刊《中國循證醫(yī)學雜志》，是全球第一本中文循證醫(yī)學雜志
jfsoft.net.cn，被Cochrane圖書館方法學組收錄的全球5本雜志中唯一一本非英文雜志，國內(nèi)臨床綜合類100雜志中位居第4。2008年與世界第二大圖書出版公司聯(lián)合創(chuàng)辦英文版循證醫(yī)學雜志（Journal of Evidence Based Medicine)，與UK Cochrane中心主任共同擔任主編，向全球公開發(fā)行，2010年年底先后被Medline、Embase收錄。在國內(nèi)最早開展循證藥物評價、
器械評價、新藥評審、風險管理和藥物經(jīng)濟學、基本藥物篩選和制度建設(shè)的系列研究與探索，最早發(fā)表系列書稿、文章和研究報告。應(yīng)邀參編我國第一本藥物經(jīng)濟學指南，本科生教材，是中國藥學會第一屆“藥物經(jīng)濟學委員會”委員和“藥物臨床評價委員會”委員。創(chuàng)辦循證篩選基本藥物、循證評價上市后藥物、循證醫(yī)學與新藥審評、循證管理藥物不良反應(yīng)及汶川地震醫(yī)療救治中的藥品管理和費用分析、中藥療效評價方法研究培訓班和講座。
1. L. Feng, Y. Guo, F. Cheng, S. Li, L. Wei, D. Long, Q. Li, and Y. Li。Effects of Pretreatment With Yisheng Injection on Renal Warm Ischemia/Reperfusion Injury in Mice. Transplant Proc, 2010; 42(10): 1545-1549.
2. Wei L, Lu J, Feng L, Long D, Shan J, Li S, Li Y. HIF-1alpha accumulation upregulates MICA and MICB expression on human cardiomyocytes and enhances NK cell cytotoxicity during hypoxia-reoxygenation. Life Sci. 2010, 87: 111-119.
3. Chuntao Zhang, Juan Shan, Jun Lu, Yuchuan Huang, Li Feng, Dan Long, Shengfu Li, Quansheng Li,Youping Li. Rapamycin in combination with donor-specific CD4+CD25+Treg cells amplified in vitro might be realize the immune tolerance in clinical organ transplantation. Cellular Immunology 264 (2010) 111–113
4. Chuntao Zhang, Juan Shan, Jun Lu, Yuchuan Huang, Li Feng, Dan Long, Shengfu Li, Quansheng Li,Youping Li. Combination of rapamycin and IL-2 do not affect antigen presentation ability of rat B cell and could promote Tregs proliferation and inhibitory activity. Cellular Immunology 264 (2010) 180–185
5. Xiao Z, Shan J, Li C, Luo L, Feng L, Lu J, Li S, Long D, Li Y. CrmA gene transfer rescued CsA-induced renal cell apoptosis in graft kidney. Cell Immunol. 2010;265(1):6-8.
6. Feng L, Pang L, Guo Y, Ke N, Li S, Wei L, Li Q, Li Y. Hypoxia/reoxygenation up-regulates death receptor expression and enhances apoptosis in human biliary epithelial cells. Life Science. 2009,26; 85(9-10):401-407.
7. Huang Y, Shan J, Wang C, Ma J, Li D, Li L, Li SF, Li YP Can ischemic preconditioning alone really protect organs from ischemia reperfusion injury in transplantation. Transplant Immunology. 2009, 20(3):127-131.
8. L. Feng, N. Ke, Z. Ye, Y. Guo, S. Li, Q. Li, and Y. Li. Expression of nkg2d and its ligand in mouse heart allografts may have a role in acute rejection. Trans proc, 2009; 41(10): 4332-4339.
9. Liang Wei, Jun Lu, Li Feng, Shengfu Li, Juan Shan, Youping Li*. Construction of recombinant adenovirus vector
jfsoft.net.cn containing a modified gene that codes for human hypoxia-inducible factor-1<alpha> without oxygen-dependent degradation domain. Plasmid (SCI) 2010; 63(1):20-26.
10. Ke NW, Fen L, Xu L, Shan J, Lei JJ, Zhang CT, Li YP. B7-1 induces immunosuppression when expressed in cultured neonatal mice keratinocytes. Immunobiology 2009, 214: 653–663
11. Yuchuan Huang, Juan Shan, Shujuan Yang, Fuchang Zheng, Jungang Zhang, Youping Li*. Donor-specific regulatory T cells might be used to induce tolerance in solid organ transplantation. Medical hypotheses, 2008, 71(4):602-604.
12. Cheng F, Li Y*, Feng L, Li S. Effects of tetrandrine on ischemia/reperfusion injury in mouse liver. Transplant Proc. 2008;40(7):2163-6
13. Cheng F, Li Y*, Feng L, Li S. Hepatic stellate cell activation and hepatic fibrosis induced by ischemia/reperfusion injury. Transplant Proc. 2008; 40(7):2167-70.
14. Feng L, Zhao N, Yao X, Sun X, Du L, Diao X, Li S, Li Y*. Histidine-tryptophan-ketoglutarate solution vs. University of Wisconsin solution for liver transplantation: a systematic review. Liver Transpl. 2007;13(8):1125-36.
15. Tang Y, Li YP*, Li JS, Zhang ZD, Han FH, Hu WM, Tian BL.Impact of portal versus systemic venous drainage on acute rejection of simultaneous pancreas-kidney transplantation in pig.Transplantation. 2007 15;84(5):629-33.
16. Feng L, Cheng F, Ye Z, Li S, He Y, Yao X, Q Tang, Y Li*. The effect of renal ischemia-reperfusion injury on expression of RAE-1 and H60 in mice kidney. Transplant Proc 2006;38(7):2195-2198.
17. He Y, Li S, Feng L, Cheng F, Ye Z, Li Y*. Effect of cyclosporine on expression of MIC in human hepatocytes. Transplant Proc 2006; 38(7): 2231-2233.
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