三、在研的主要項(xiàng)目
1.近年主要研究課題
(1) 哮喘發(fā)病的分子機(jī)制和干預(yù)策略研究,國(guó)家杰出青年科學(xué)基金。
(2) 呼吸疾病基礎(chǔ)――磷酸酶SHP2信號(hào)在肺損傷和異常修復(fù)中的調(diào)控機(jī)制,國(guó)家973項(xiàng)目。
(3) 趨化素樣因子1衍生多肽作為候選新藥的研究與開(kāi)發(fā), 國(guó)家863項(xiàng)目。
(4) TLR4-PKC-Duox1信號(hào)通路在PA-LPS上調(diào)氣道粘蛋白MUC5AC中的作用,國(guó)家自然科學(xué)基金。
(5) 中醫(yī)藥在哮喘階梯式治療中優(yōu)化方案的研究,十一五國(guó)家科技支撐計(jì)劃課題。
代表論文
主要SCI收錄論文
1. Jiyong J, Tiancha H, Wei C, Huahao S. Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in bacterial infection: a meta-analysis. Intensive Care Med. 2009,35(4):587-595.
2. Jing JY, Huang TC, Cui W, Xu F, *Shen HH. Should FEV1/FEV6 replace FEV1/FVC ratio to detect airway obstruction? A metaanalysis.Chest. 2009, Apr;135(4):991-8.
3. Li Q, *Shen HH. Neonatal bacillus Calmette-Guérin vaccination inhibits de novo allergic inflammatory response in mice via alteration of CD4+CD25+ T-regulatory cells. Acta Pharmacol Sin. 2009 Jan;30(1):125-33.
4. Zhang GS, Wang PL, Huang HQ, *Shen HH. New insights into the effects of Mycobacterium bovis Bacillus Calmette-Guérin on asthma.Chin Med J (Engl). 2009 Mar 5;122(5):577-83.
5. Wang P, Zhang G, *Shen HH. Multiple synchronous primary malignancies induced by benzene exposure: a case report. J Occup Med Toxicol. 2009 Apr 16;4:7.jfsoft.net.cn
6. Gao GX, Li QM, *Shen HH. Effect of Astragali-Cordyceps Mixtura on TGF-beta/Smad signal pathway in the lung of Asthma Airway Remodeling. J Ethnopharmacol. 2009 Jun 20. [Epub ahead of print]
7. *Shen H, Huang H, Wang J, Ye S, Li W, Wang K, Zhang G, Wang P. Neonatal vaccination with Bacillus Calmette-Guerin elicits long-term protection in mouse allergic responses. Allergy ,2008, 63: 555-563.
8. Ben SQ, Li XB, Xu F, Xu WH, Li W, Wu ZQ, Huang HQ, Shi GZ, *Shen HH. Treatment with anti-CCR3 monoclonal antibody or dexamethasone inhibits the migration and differentiation of bone marrow CD34+ progenitor cells in an allergic mouse model. Allergy, 2008 Sep;63(9):1164-76.
9. *Shen HH, Yoshida H, Yan FG, Li W, Xu F, Huang HQ, Jono H, Li JD. Synergistic induction of MUC5AC mucin by nontypeable Haemophilus influenzae and Streptococcus pneumoniae. BBRC, 2008, 365(4):795-800.
10. Fugui Yan, Hirofumi Jono, Jian-Dong Li,*Shen HH. Reactive oxygen species regulates Pseudomonas aeruginosa Lipopolysaccharide-induced MUC5AC mucin expression via PKC-NADPH oxidase-ROS-TGF-alpha signaling pathways in human airway epithelial cells. BBRC , 2008,366: 513–519.
11. Liu GN, Shi HZ, Xie ZH, Shen HH, Huang HQ, Deng JM, Liang QL, Wu YB. Epithelial Neutrophil-Activating Peptide-78 Recruits Neutrophils into Pleural Effusion.Eur Respir J. 2008 Dec 1. [Epub ahead of print]
12. Xu F, Xu ZH, Zhang R, Wu ZQ, Li JD, *Shen HH. Nontypeable Haemophilus influenzae induces COX-2 and PGE2 expression in lung epithelial cells via activation of p38 MAPK and NF-kappa B. Respiratory Research 2008, 9(1):16。